Endocrinology and Diabetology

Unit

Clinical activity

The Endocrinology and Diabetology Unit carries out clinical-assistance activities for the treatment of diabetes, thyroid diseases, obesity and other endocrine diseases.

Main  clinical activities include:

  • Outpatient visits for the clinical assessment of endocrine disorders
  • Ultrasound and thyroid needle aspirate
  • Prevention and treatment of diabetes and chronic complications
  • Individual and group therapeutic education courses for people with type 1 and type 2 diabetes
  • Prevention and treatment of obesity and metabolic syndrome (with group psycho-educational courses)
  • Diagnostic investigation for thyroid diseases

Services are provided in conjunction with the National Health Service, and privately, outpatient and in Day Hospital. Special cases, such as the study of severe hypoglycaemia and diabetic ketoacidosis, are treated under ordinary hospitalisation.

Patient in care can use a direct telephone service and e-mail to communicate directly with the health professionals.

The Unit also carries out outpatient and research activities, complementary to those carried out on site, at the Ceccano hospital centre, the hospitals of Sora and Cassino (Frosinone Local Health Authority).

Within the Endocrinology and Diabetology Unit operates the Unit for Metabolic Diseases.

Research fields

Pathogenesis and immunotherapy of type 1 diabetes

  • Use of innovative therapies to protect residual beta cells at the onset of type 1 diabetes using international immunotherapy protocols. Study of the role of post-translational oxidative modifications (oxPTM) in diabetes autoimmunity
  • Study and validation of the ELISA assay on post-translational modifications (oxPTM) in Adult Autoimmune Latent Diabetes(LADA)
  • Post-translationally modified insulin as a therapeutic target in type 1 diabetes, Juvenile Diabetes Research Foundation (JDRF), USA
  • Antibodies against post-translationally modified insulin as a biomarker in type 1 diabetes. European Foundation for the Study of Diabetes (EFSD)/JDRF/Lilly

Type 2 diabetes, obesity and diet

  • Pancreatic ß-cell identity, glucose sensing and the control of insulin secretion
  • Effects of modified hyperglycaemia / insulin on adipogenic differentiation of mesenchymal cells extracted from the subcutaneous fat of obese and diabetic patients
  • Evaluation of the molecular mechanisms of insulin resistance in vitro
  • Role of the endocannabinoid system in type 2 diabetes, in collaboration with the Research Unit of Biochemistry and Molecular Biology UCBM

Bone and associated pathologies (pathophysiological mechanisms of bone fragility in subjects with diabetes, obesity and post-menopausal women)

  • Evaluation of bone quality and WNT signalling in obese patients (Grant from the University Campus Bio-Medico of Rome)
  • Evaluation of WNT system activation by sclerostin assay in patients with type 2 diabetes and in patients with latent autoimmune diabetes in adults (LADA)
  • Assessment of risk factors for bone fragility fractures in type 1 diabetes
  • Evaluation of the role of mechanical loading and WNT signalling on bone marrow adiposity (BMA) and on bone formation in type 1 diabetes (in collaboration with the department of Bone and Mineral Diseases, Washington University of St Louis)

Clinical and research collaboration

  • University of California, San Francisco, USA
  • Nanyang Technological University, Singapore
  • Washington University, Saint Louis, USA
  • Wayne State University School of Medicine in Detroit, USA
  • Blizard Institute, Barts and the London School of Medicine, Queen Mary, University of London, UK
  • Joslin Diabetes Center, Harvard, Boston, USA
  • International Diabetes Center, Atlanta, USA
  • Peking University People’s Hospital, China
  • Hadassah Center for the Prevention of Diabetes, Jerusalem, Israel
  • The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, China

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