Osteo-metabolic and Thyroid Pathologies

Unit

The Complex Operative Unit (UOC) of Osteo-metabolic and Thyroid Pathologies carries out clinical-assistance activities at the Campus Bio-Medico University Hospital of Rome and at the Campus outpatient clinics in the Frosinone Local Health Authority (Ceccano Health Centre, Frosinone, Sora and Cassino hospitals).

The main clinical services at the Campus Bio-Medico University Hospital are:

  • Outpatient examinations for clinical assessment of:
    • osteoporosis and bone fragility
    • prevention and treatment of bone fragility in obese and diabetic patients
    • pathologies of the parathyroid glands and of the calcium-phosphorus metabolism
    • thyroid pathologies including the management of thyroid carcinoma
  • Ultrasound, fine needle aspiration and core biopsy (microbiopsy) of the thyroid.
  • Infusion of substances for the management of bone fragility, Paget's disease and Sudek's syndrome.
  • Coordination with other UOCs of the interdisciplinary fragility fracture pathway (innovative service for the secondary prevention of fragility fractures).

The main clinical services at the Local Health Authority in Frosinone are:
Prevention and treatment of type 1 and type 2 diabetes and chronic complications

  • Diagnosis and therapy of endocrine disorders
  • Thyroid ultrasound and fine needle aspiration
  • Osteoporosis and bone fragility in various clinical conditions
  • Pathologies of calcium-phosphorus metabolism
  • Individual and group therapeutic education courses for people with type 1 and type 2 diabetes
  • Endocrine and metabolic disorders in the paediatric age group
  • Erectile dysfunction and andrological diseases

Services are provided in agreement with the Italian National Health Service and with private health schemes, on an outpatient basis. Specific cases, such as the study of severe thyroid diseases or complex bone diseases, are treated on a normal in-patient basis.

Every patient in care can use an e-mail service to communicate directly with the health professionals.

Areas of Research

Diabetes and bone fragility

  • Diabetes and bone fragility
    • Assessment of inflammation and biological pathways causing bone fragility and sarcopenia in obese and diabetic patients
    • Assessment of clinical risk factors for bone fragility in type 1 and type 2 diabetes
    • Effect of high-fibre diets on adipose tissue, muscle and bone health
    • Effect of high doses of vitamin D on inflammation, adipogenesis and WNT pathway
  • Prevention of osteoporosis and fragility fractures
    • Assessment of genetic factors associated with bone loss
    • Assessment of inflammation on bone microarchitecture and fracture risk
    • Effect of anti-resorptive and anabolic drugs on the imminent and long-term risk of fracture
    • Role of the microbiome on bone microarchitecture and fracture risk
    • Use of new DEXA-derived tools for the assessment of bone quality in secondary osteoporosis
  • Calcium-phosphorus metabolism
    • Assessment of the impact of chronic PTH elevation on adipose tissue and the gut microbiome and metabolic changes after parathyroidectomy
    • Assessment of the impact of hyperparathyroidism secondary to vitamin D deficiency on irisin
    • Assessment of the impact of PTH on endothelial cell activation/dysfunction and platelet reactivity
    • Ophthalmological assessment and of the central nervous and neurovegetative system function in patients with chronic hypoparathyroidism
    • Replacement therapy with parathormone analogues in patients with chronic hypoparathyroidism
  •  Immunotherapy of type 1 diabetes
    • Use of innovative therapies in protecting residual beta cells at the onset of type 1 diabetes
  • Characterisation and definition of latent autoimmune diabetes of adults (LADA)
  • Long-term COVID and fragility
  • Diabetes and the microbiome
    • Role of the microbiome as a risk factor for insulin resistance and type 2 diabetes
    • Microbiome as mediator of inflammation in type 2 diabetes
  • Thyroid
    • Assessment of thyroid cytology by Raman spectroscopic analysis in order to improve the diagnostic accuracy of thyroid carcinoma
    • New approaches used to identify molecular alterations related to ongoing malignant transformations in thyroid adenomas using Raman spectroscopy.

Clinical and research collaboration

  • Washington University, Saint Louis, USA
  • University of California, San Francisco, USA
  • Columbia University, New York, USA
  • Baylor College of Medicine
  • University of Sheffield, UK
  • Consorzio Europeo ‘’ FIDELIO’’
  • Blizard Institute, Barts and the London School of Medicine, Queen Mary, University of London, UK
  • International Diabetes Center, Atlanta, USA
  • Clinic for Endocrinology, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
  • Joslin Diabetes Center, Harvard, Boston, USA
  • International Diabetes Center, Atlanta, USA
  • Peking University People’s Hospital, China
  • Hadassah Center for the Prevention of Diabetes, Jerusalem, Israel
  • The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, China