Virology

Unit

Clinical activity

The Virology Unit, part of Analysis Laboratory, carries out serological and molecular virology investigations on the main viral infections.

In particular, it deals with research on the main viruses causing infectious hepatitis (A, B, C, D, E), the virus causing acquired immunodeficiency syndrome (AIDS), the main pathogens responsible for teratogenic congenital infections (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes simplex, Parvovirus B19), infectious mononucleosis virus (Epstein Barr), viruses responsible for mumps and exanthematous diseases (Parvovirus B19, Measles, Varicella/Zoster), detection and typing of viruses associated with viral infections of the skin and mucosa (Papillomavirus HPV).

It also carries out molecular diagnostic investigations for the main viruses involved in infections of the respiratory system, the Central Nervous System, and gastroenteritis. We have syndromic molecular panels that allow for the multiplex detection of several pathogens and that are useful for a rapid broad-spectrum differential diagnosis (syndromic panels for neurotropic, respiratory and gastroenteric viruses).

Thanks to the advanced molecular biology tools available, such as automatic and semiautomatic nucleic acid extraction systems, qualitative-quantitative real-time PCR systems, Array systems, Pyrosequencing systems, strip hybridization systems, the Virology Unit also deals with:

  • Complete virological monitoring of infection and response to therapy of chronic hepatitis B and C viruses (viremia and genotype)
  • Complete virological monitoring of infection and response to therapy during Cytomegalovirus infection
  • Analysis of genetic polymorphisms associated with persistent infectious diseases (IL28B, IFN lamda4, TLR, etc.)

The Virology unit operates within the Analysis Laboratory. The list of services and the related regimen is available on the page of the Sample collection laboratory. To access services, you can contact the Sample collection laboratory directly, with no need to book.

Research fields

  • Basic virology
  • Clinical virology
  • Viral and host factors influencing the clinical course and/or response to treatment of certain viral infections: HCV infection, in terms of progression and response to treatment, CMV infection, in terms of clinical course and reactivation, mucosal HPV infection, in terms of spontaneous clearance and/or progression of lesions
  • Clinical progress and/or response to treatment of certain viral infections in haematological subjects after transplants
  • Migrants and Health
  • Study of respiratory infections in fragile and paediatric populations

Collaboration

  • Department of Molecular Medicine and Virology Unit, Sapienza University of Rome
  • AIFA (Italian Medicines and Healthcare products Regulatory Agency)
  • IRCCS OPBG (Ospedale Pediatrico Bambino Gesù)
  • SIM (società Italiana di Microbiologia)

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