Clinical Pharmacology


Clinical activity

The Clinical Pharmacology Unit provides services for inpatients and outpatients, both in agreement with the National Health Service and as private service.
It is specialised in quantifying plasma levels of numerous drugs of clinical importance:

  • Neurological (valproic acid, carbamazepine, phenytoin, phenobarbital, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, peramapanel, topiramate, zonisamide)
  • Antiarrhythmics (amiodarone / desethylamiodarone)
  • Antibiotics (amikacin, vancomycin, gentamicin, linezolid)
  • Antifugals (posaconazole, isavuconazole, voriconazole)
  • Onco-haematology (methotrexate)

The Clinical Pharmacology Unit also provides espertise for Ethics Committees, Phase I Clinical Research, Pharmacotherapeutic advise.

Research fields

  • Validation and development of new methods of Tandem Mass Spectrometry for drug matrix dosing and metabolomics of clinical importance
  • Clinical and preclinical pharmacokinetics and pharmacodynamics of cancer drugs

The Unit is internationally known for

  • Cardiovascular toxicity of cancer drugs
  • Translational models of human heart exposure to cancer drugs
  • Clinical pharmacokinetic determinants of cancer drugs efficacy and safety

Clinical and research collaborations

  • Incyte BioSciences Europe
  • EUREKA Lab Division s.r.l.

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