Immunorheumatology Unit


The Immunorheumatology Unit is multi-speciality care and consists of an integrated team of staff with predominant experience in Internal Medicine with specific competencies in immunorheumatology, hepatology and nephrology.


The Rheumatology service treats a wide range of case histories relating to systemic autoimmune diseases (e.g. systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, systemic sclerosis, poly- dermatomyositis), vasculitis and spondyloarthritis, pathologies involving multiple organs and systems, and accompanied by relevant co-morbidities (cardiovascular illnesses, metabolic syndrome, interstitial lung disease, osteoporosis, etc.). Complex cases are treated on an inpatient basis.


The Unit is able to provide the patient with a complete and rapid diagnostic pathway within its own facilities, having, as it does, access to a team of dedicated staff to carry out both laboratory diagnostics for immune-mediated conditions and instrumental diagnostics (multi-zone ultrasound, echo-colour Doppler, capillaroscopy, BMD-DEXA). The ultrasound service has dedicated provision for the study of articulation problems during both the early stages of arthritis (early diagnosis) and in subsequent monitoring.


It also operates day surgeries for integrated diagnostics in the multidisciplinary treatment of osteoporosis (in collaboration with the Orthopaedics and Traumatology Unit) and for infusion therapies. There is also an outpatient clinic for the diagnosis and treatment of allergy-related conditions.


The Unit is recognised by the Lazio Region as an accredited centre for the dispensing of biological medicines used in the treatment of rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Patients who do not respond to traditional therapies are thus guaranteed access to the most advanced therapies.


Within the Immunorheumatology Unit operates the Hepatology Unit.


  • Systemic auto-immune illnesses, with particular interest in cell-mediated immune response and
    the role of particular auto-antibodies and cytokines in the pathogenesis of connective tissue, such as systemic lupus erythematosus and rheumatoid arthritis (including cardiovascular involvement)
  • Clinical, instrumental and laboratory parameters on the status of endothelial function and dysfunction (altered release of vasoactive substances)
  • Activators of the coagulation cascade and/or deficits of inhibitors in systemic auto-immune pathologies
  • New immuno-modulating biologically-targeted therapies in pre-clinical and clinical fields (anti-cytokine and anti-receptor cellular material)
  • Physiopathological alterations typical of the advanced stages of illness in the pre-cirrhotic stages of chronic hepatopathology (evolutionary mediators of hepatic fibrosis, endocrine-metabolic alterations of the respiratory function and pulmonary microcirculation)


  • Department of Clinical Medicine, Immunology and Infectious Diseases, University of Bari
  • Italian Association for the Study of the Liver (A.I.S.F.)
  • Department of Clinical Medicine, La Sapienza University of Rome
  • Department of Internal Medicine and Medical Specialities (DIMI), University of Genoa
  • Department of Internal Medicine, Mayo Clinic, Scottsdale, USA
  • Department of Internal Medicine, University of Navarra, Pamplona, Spain
  • Interdisciplinary Forum on Auto-immune Illnesses Research (F.I.R.M.A.)
  • Italian Society of Internal Medicine (S.I.M.I.)
  • Multi-centre international clinical trials, financed by the Ministry for Universities and Research,
    for finalised research (Research Projects of National interest [PRIN], 2007)


Tel.: (+39) 06.22541.1613 | Fax: (+39) 06.22541.1256


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